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Papers of the Week

2020 Jul 09


Peri-Infarct Hot-Zones Have Higher Susceptibility to Optogenetic Functional Activation-Induced Spreading Depolarizations.


Sugimoto K, Chung DY, Böhm M, Fischer P, Takizawa T, Aslihan Aykan S, Qin T, Yanagisawa T, Harriott A, Oka F, Yaseen MA, Sakadžić S, Ayata C
Stroke. 2020 Jul 09:STROKEAHA120029618.
PMID: 32640946.


Spreading depolarizations (SDs) are recurrent and ostensibly spontaneous depolarization waves that may contribute to infarct progression after stroke. Somatosensory activation of the metastable peri-infarct tissue triggers peri-infarct SDs at a high rate.