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Papers of the Week

2020 Jul 08

J Nanobiotechnology



Intra-articular delivery of celastrol by hollow mesoporous silica nanoparticles for pH-sensitive anti-inflammatory therapy against knee osteoarthritis.


Jin T, Wu D, Liu X-M, Xu J-T, Ma B-J, Ji Y, Jin Y-Y, Wu S-Y, Wu T, Ma K
J Nanobiotechnology. 2020 Jul 08; 18(1):94.
PMID: 32641147.


Celastrol has been proven effective in anti-inflammatory but was limited in the clinic due to the poor solubility and side effects induced by low bioavailability. Osteoarthritis has acidic and inflammatory environment. Our aim was to load celastrol into HMSNs and capped with chitosan to construct a pH-responsive nanoparticle medicine (CSL@HMSNs-Cs), which is of high solubility for osteoarthritis intra-articular injection treatment.