I am a
Home I AM A Search Login

Papers of the Week

2020 Jul 10

Mod Rheumatol

Prevention of bone loss and improvement of pain-related behavior in hind limb-unloaded mice by administration of teriparatide and bisphosphonate.


Miyamura G, Wakabayashi H, Nagao N, Kato S, Nakagawa T, Naito Y, Sudo A
Mod Rheumatol. 2020 Jul 10:1-10.
PMID: 32646253.


There are few reports on the comparison between teriparatide (PTH) and bisphosphonate (BP) in terms of osteoporosis pain-related behavior and immunohistochemical findings. The aims of this study were to evaluate skeletal pain associated with osteoporosis and to examine the inhibitory effect of PTH and BP on pain and bone loss in hind limb-unloaded (HU) mice. The mechanism of osteoporotic pain in HU mice was evaluated by examining pain-related behavior and immunohistochemical findings. The effects of PTH and alendronate (ALN), a potent osteoclast inhibitor, on these parameters were also assessed.