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Papers of the Week

Papers: 11 Jul 2020 - 17 Jul 2020

Human Studies

2020 Jul 10

Eur J Pain

Sustained perturbation in functional connectivity induced by cold pain.


Makovac E, Dipasquale O, Jackson JB, Medina S, O'Daly O, O'Muircheartaigh J, de Lara Rubio A, Williams SCR, McMahon SB, Howard MA
Eur J Pain. 2020 Jul 10.
PMID: 32648623.


Functional connectivity (FC) perturbations have been reported in multiple chronic pain phenotypes, but the nature of reported changes varies between cohorts and may relate to the consequences of living with chronic-pain related comorbidities, such as anxiety, and depression. Healthy volunteer studies provide opportunities to study the effects of tonic noxious stimulation independently of these sequelae. Connectivity changes in task negative and positive networks, for example, the default mode and salience networks (DMN/SN), respectively, have been described, but how these and other connectivity networks, for example, those governing descending pain control are affected by the presence of tonic, noxious stimulation in healthy, pain-free individuals remains unknown.