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Papers of the Week


2020 Jul 01


Pharmacol Rep

Synthesis and pharmacological evaluation of novel cis and trans 3-substituted anilidopiperidines.

Authors

Jevtić II, Vujović K S, Srebro D, Vučković S, Ivanović MD, Kostić-Rajačić SV
Pharmacol Rep. 2020 Jul 01.
PMID: 32613543.

Abstract

4-Anilidopiperidine class of synthetic opioid analgesics, with it's representative fentanyl, are by far the most potent and clinically significant for the treatment of the severe chronic and surgical pain. However, side effects of μ-opioids are often quite serious. In order to improve the pharmacological profile of this class of opioid analgesics, a novel fentanyl analogs were designed, synthesized and evaluated in vivo for their antinociceptive activity.