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Papers of the Week

Papers: 27 Jun 2020 - 3 Jul 2020

Human Studies


2020 Jun 26


Serum levels of allopregnanolone, progesterone and testosterone in menstrually-related and postmenopausal migraine: A cross-sectional study.


Rustichelli C, Bellei E, Bergamini S, Monari E, Baraldi C, Lo Castro F, Tomasi A, Ferrari A
Cephalalgia. 2020 Jun 26:333102420937742.
PMID: 32588652.


Reduced blood or cerebrospinal fluid levels of allopregnanolone are involved in menstrual cycle-linked CNS disorders, such as catamenial epilepsy. This condition, like menstrually-related migraine, is characterized by severe, treatment-resistant attacks. We explored whether there were differences in allopregnanolone, progesterone and testosterone serum levels between women with menstrually-related migraine (MM, n = 30) or postmenopausal migraine without aura who had suffered from menstrually-related migraine during their fertile age (PM, n = 30) and non-headache control women in fertile age (FAC, n = 30) or post-menopause (PC, n = 30).