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Papers of the Week


2020 Jun 26


Oncologist

Systemic Steroid Treatment for Imatinib-Associated Severe Skin Rash in Patients with Gastrointestinal Stromal Tumor: A Phase II Study.

Authors

Kim E J, Ryu M-H, Park S R, Beck M Y, Lee W J, Lee M W, Kang Y-K
Oncologist. 2020 Jun 26.
PMID: 32589310.

Abstract

To achieve optimal clinical outcomes in patients with gastrointestinal stromal tumor (GIST), it is crucial to maintain sufficient dosing of imatinib. Skin rash is a common imatinib-associated adverse event and may affect compliance. This phase II study was conducted to evaluate whether imatinib-associated severe skin rash can be managed with systemic steroids without dose reduction or interruption of imatinib. This study is registered at ClinicalTrials.gov, number NCT03440515.