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Papers of the Week

Papers: 20 Jun 2020 - 26 Jun 2020

Animal Studies, Pharmacology/Drug Development


2020 Jun 24


Evaluation of LY573144 (lasmiditan) in a preclinical model of medication overuse headache.


Rau JC, Navratilova E, Oyarzo J, Johnson KW, Aurora SK, Schwedt TJ, Dodick DW, Porreca F
Cephalalgia. 2020 Jun 24:333102420920006.
PMID: 32580575.


Medication overuse is a significant issue that complicates the treatment of headache disorders. The most effective medications for the acute treatment of migraine all have the capacity to induce medication overuse headache (MOH). Novel acute migraine-specific treatments are being developed. However, because the mechanism(s) underlying medication overuse headache are not well understood, it is difficult to predict whether any particular acute medication will induce MOH in susceptible individuals. LY573144 (lasmiditan), a 5-HT receptor agonist, has recently been shown to be effective in the acute treatment of migraine in phase 3 trials. The aim of this study is to determine whether frequent administration of lasmiditan induces behaviors consistent with MOH in a pre-clinical rat model.