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Papers of the Week

Papers: 20 Jun 2020 - 26 Jun 2020

Animal Studies, Pharmacology/Drug Development

2020 Jun 17


Shift of µ-opioid Receptor Signaling in the Dorsal Reticular Nucleus Is Implicated in Morphine-induced Hyperalgesia in Male Rats.


Costa A R, Sousa M, Wilson SP, Reguenga C, Teixeira-Pinto A, Tavares I, Martins I
Anesthesiology. 2020 Jun 17.
PMID: 32568844.


Increased descending pain facilitation accounts for opioid-induced hyperalgesia, but the underlying mechanisms remain elusive. Given the role of µ-opioid receptors in opioid-induced hyperalgesia in animals, the authors hypothesized that the dorsal reticular nucleus, a medullary pain facilitatory area, is involved in opioid-induced hyperalgesia through altered µ-opioid receptor signaling.