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Papers of the Week

Papers: 20 Jun 2020 - 26 Jun 2020

Animal Studies, Pharmacology/Drug Development

2020 Jun 19

Br J Pharmacol

CB1 receptor-dependent TRPV1 desensitisation contributes to the analgesic effect of dipyrone in sensitised primary sensory neurons.


Dos Santos G G, Li R, Ng M P E, Lemes J B P, Vieira W F, Nagy I, Tambeli C H, Parada C A
Br J Pharmacol. 2020 Jun 19.
PMID: 32562269.


While dipyrone is a widely used analgesic, its mechanism of action is not completely understood. Recently we have reported that the dipyrone metabolite 4-aminoantipirine (4-AA) reduces prostaglandin E (PGE )-induced pain-related behaviour through the cannabinoid type 1 (CB1) receptor. Here, we ascertained, in naive and PGE -induced "inflamed" conditions, both in vivo and in vitro, the molecular mechanisms involved in the 4-AA-induced analgesic effects.