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Papers of the Week

2020 Jun 17

Clin Nucl Med

177Lu-/68Ga-PSMA Theranostics in Recurrent Glioblastoma Multiforme: Proof of Concept.


Kumar A, Ballal S, Yadav M P, ArunRaj ST, Haresh KP, Gupta S, Avinash Damle N, Garg A, Tripathi M, Bal C
Clin Nucl Med. 2020 Jun 17.
PMID: 32558721.


A 37-year-old man, treated case of left temporal glioblastoma presented with headache, seizures, and progressive right-sided weakness with MRI evidence of recurrence. Exploratory Ga-PSMA PET/CT demonstrated PSMA expression in the recurrent lesion; it was decided to treat this patient with Lu-PSMA-617. After 3 cycles of Lu-PSMA-617, Ga-PSMA PET/CT showed significant reduction in PSMA uptake and regression in size of lesion on MRI with improvement in patient's symptoms and performance status. Lu-/Ga-PSMA theranostics has potential in patients with recurrent glioblastoma multiforme when other therapeutic options are not feasible.