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Papers of the Week

Papers: 13 Jun 2020 - 19 Jun 2020

Animal Studies, Pharmacology/Drug Development


2020 Jun 14


Inhibition of mite-induced dermatitis, pruritus, and nerve sprouting in mice by the endothelin receptor antagonist bosentan.


Kido-Nakahara M, Wang B, Ohno F, Tsuji G, Dugarmaa U, Takemura M, Furue M, Nakahara T
Allergy. 2020 Jun 14.
PMID: 32535962.


Endothelin-1 (EDN1) can evoke histamine-independent pruritus in mammals and is upregulated in the lesional epidermis of atopic dermatitis (AD). EDN1 increases the production of interleukin 25 (IL-25) from keratinocytes to accelerate T helper type 2 immune deviation. Plasma EDN1 levels are positively correlated with the clinical severity and itch intensity of AD. Therefore, we hypothesized that the inhibition of EDN1 might be useful for treating atopic inflammation and itch and investigated the effects of the topical application of the EDN1 receptor antagonist bosentan on the skin inflammation and itch in a murine AD model.