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Papers of the Week

Papers: 13 Jun 2020 - 19 Jun 2020

Animal Studies

2020 Jun 12

J Oral Pathol Med

NMDA and Purinergic Processes Modulate Neck Muscle Activity Evoked by Noxious Stimulation of Dura.


Yao D, Li J, Yoshida M, Sessle BJ
J Oral Pathol Med. 2020 Jun 12.
PMID: 32531859.


Adenosine triphosphate (ATP) and glutamate are associated with some headache conditions, and purinergic (P2X) and glutamatergic N-methyl-D-aspartate (NMDA) receptor-related processes in the medulla can modulate the effects of trigeminal nociceptive afferent inputs into the brainstem on craniofacial sensorimotor circuits. This study aimed to test whether neck muscle activity can be induced in rats by noxious stimulation of the frontal dura or superior sagittal sinus that involves P2X or NMDA receptor-dependent mechanisms.