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Papers of the Week

Papers: 6 Jun 2020 - 12 Jun 2020

Human Studies


2020 Jun 10

J Eur Acad Dermatol Venereol

Immunohistochemistry Analysis of Itch and Pain Mediators in Nonmelanoma Skin Cancer.


Fowler E, Rosen J, Shah SM, Strowd L, Tang JC, Nattkemper LA, Yosipovitch G
J Eur Acad Dermatol Venereol. 2020 Jun 10.
PMID: 32519332.


Patients with nonmelanoma skin cancer (NMSC) may experience symptoms of itch and pain, which we previously reported to be associated with overall degree of inflamation . Specific mediators underlying itch and pain in NMSCs have not been studied, so immunohistochemistry was performed for mediators involved in these pathways. 60 subjects from a tissue repository were included in this study for a total of 50 histopathologically confirmed NMSCs and 10 healthy controls. Participants were asked to rank their current itch and pain intensities at the time and location of biopsy on a 11-point numerical rating scale (NRS).