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Papers of the Week
FcγRI-coupled signaling in peripheral nociceptors mediates joint pain in a rat model of rheumatoid arthritis.
Abstract
Rheumatoid arthritis (RA) is often accompanied by joint pain and inflammation. Previous studies demonstrated that functional FcγRI was expressed in dorsal root ganglion neurons, and might contribute to pain in rodent models of antigen-induced arthritis (AIA). This study was performed to elucidate the roles of nociceptive neuronal FcγRI-coupled signaling in the development of joint pain in AIA.