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Papers of the Week

2020 Jun 04

Cent Nerv Syst Agents Med Chem

Drug Repositioning: Antimalarial Activities of GABA Analogs in Mice Infected with Plasmodium berghei.


Ayankunle A, Wakeel O, Kolawole O, Oyekale A, Ojurongbe O, Adeyeba O
Cent Nerv Syst Agents Med Chem. 2020 Jun 04.
PMID: 32496991.


Drug repositioning is becoming popular due to the development of resistance to almost all the recommended antimalarials. Pregabalin and gabapentin are chemical analogs of gamma-aminobutyric acid (GABA) approved for the treatment of epilepsy and neuropathic pain.