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Papers of the Week


Papers: 30 May 2020 - 5 Jun 2020


Human Studies, Pharmacology/Drug Development


2020 Jun 04


Br J Clin Pharmacol

Plasma and cerebrospinal fluid pharmacokinetics of ondansetron in humans.

Authors

Chiang MD, Frey K, Lee C, Kharasch ED, Tallchief D, Sawyer C, Blood J, Back H-M, Kagan L, Haroutounian S
Br J Clin Pharmacol. 2020 Jun 04.
PMID: 32495990.

Abstract

Changes in serotonergic sensory modulation associated with overexpression of 5-HT receptors in the CNS have been implicated in the pathophysiology of neuropathic pain after peripheral nerve damage. 5-HT receptor antagonists such as ondansetron can potentially alleviate neuropathic pain, but have limited effectiveness, due potentially to limited CNS access. However, there is currently limited information on CNS disposition of systemically-administered 5-HT receptor antagonists. This study evaluated the cerebrospinal fluid (CSF) disposition of ondansetron, as a surrogate of CNS penetration.