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Papers of the Week

Papers: 30 May 2020 - 5 Jun 2020

Animal Studies, Pharmacology/Drug Development

2020 Jun 02

ACS Nano

Phospholipase A Inhibitor-Loaded Phospholipid Micelles Abolish Neuropathic Pain.


Kartha S, Yan L, Ita ME, Amirshaghaghi A, Luo L, Wei Y, Tsourkas A, Winkelstein BA, Cheng Z
ACS Nano. 2020 Jun 02.
PMID: 32484651.


Treating persistent neuropathic pain remains a major clinical challenge. Current conventional treatment approaches carry a substantial risk of toxicity and provide only transient pain relief. In this work, we show that the activity and expression of the inflammatory mediator secretory phospholipase-A (sPLA) enzyme increases in the spinal cord after painful nerve root compression. We then develop phospholipid micelle-based nanoparticles that release their payload in response to sPLA activity. Using a rodent model of neuropathic pain, phospholipid micelles loaded with the sPLA inhibitor, thioetheramide-PC (TEA-PC), are administered either locally or intravenously at the time of painful injury or 1-2 days afterwards. Local micelle administration immediately after compression prevents pain for up to 7 days. Delayed intravenous administration of the micelles attenuates existing pain. These findings suggest that sPLA inhibitor-loaded micelles can be a promising anti-inflammatory nanotherapeutic for neuropathic pain treatment.