I am a
Home I AM A Search Login

Papers of the Week

Papers: 30 May 2020 - 5 Jun 2020

Animal Studies

2020 May 29

J Neuroinflammation



TDAG8 deficiency reduces satellite glial number and pro-inflammatory macrophage number to relieve rheumatoid arthritis disease severity and chronic pain.


Dai S-P, Hsieh W-S, Chen C-H, Lu Y-H, Huang H-S, Chang D-M, Huang S-L, Sun W-H
J Neuroinflammation. 2020 May 29; 17(1):170.
PMID: 32471455.


The autoimmune disease rheumatoid arthritis (RA) affects approximately 1% of the global population. RA is characterized with chronic joint inflammation and often associated with chronic pain. The imbalance of pro-inflammatory and anti-inflammatory macrophages is a feature of RA progression. Glial cells affecting neuronal sensitivity at both peripheral and central levels may also be important for RA progression and associated pain. Genetic variants in the T cell death-associated gene 8 (TDAG8) locus are found to associate with spondyloarthritis. TDAG8 was also found involved in RA disease progression and associated hyperalgesia in the RA mouse model. However, its modulation in RA remains unclear.