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Papers of the Week

2020 May 27

Aliment Pharmacol Ther

Systematic review with meta-analysis: efficacy and safety of treatments for opioid-induced constipation.


Vijayvargiya P, Camilleri M, Vijayvargiya P, Erwin P, Hassan Murad M
Aliment Pharmacol Ther. 2020 May 27.
PMID: 32462777.


When opioid-induced constipation is treated with centrally acting opioid antagonists, there may be opioid withdrawal or aggravation of pain due to inhibition of μ-opioid analgesia. This led to the development of peripherally acting μ-opioid receptor antagonists (PAMORAs).