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Papers of the Week

Papers: 30 May 2020 - 5 Jun 2020

Human Studies


2020 May 25


Mitochondrial migraine; a prevalence, impact and treatment efficacy cohort study.


Tiehuis LH, Koene S, Gj Saris C, Ch Janssen M
Mitochondrion. 2020 May 25.
PMID: 32464279.


Mitochondrial respiratory chain dysfunction may be predisposing for the development of migraine, reflected in high migraine prevalence in patients with mitochondrial disease. Prevalence and impact of migraine in patients with proven mitochondrial disease and the current treatment efficacy were studied using online questionnaires. Patients were selected at the Internal Medicine Department. Headache was reported by 34 (55%) out of 62 patients. Migraine-criteria were met by 85% of them. Efficacy of migraine treatment was achieved in 4 patients. Given the high prevalence of migraine and current treatment insufficiency, migraine is a major threat of quality of life patients with mitochondrial disease.