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Papers of the Week
Managing long-term high-dose prescription opioids in patients with non-cancer pain: The potential role of sublingual buprenorphine.
Abstract
Opioids are frequently used to manage chronic non-cancer pain despite the lack of evidence of benefit and clear evidence of opioid-related harms. Patients undergoing high-dose opioid therapy are at risk of multiple complications, such as opioid toxicity, including fatal overdose and opioid dependence.