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Papers of the Week
Conversion from Tacrolimus IR (Twice Daily) or Cyclosporine to Tacrolimus XR (Envarsus®, Once Daily) in Lung Transplant Recipients.
Abstract
Calcineurin inhibitors are the backbone of lung transplant (LT) immunosuppression regimens. The aim of this observational review is to evaluate the use of tacrolimus XR (LCP-Tac, Envarsus®) in LT recipients at various clinical stages from cyclosporine or tacrolimus IR (Tac-IR). Due to the favorable pharmacokinetics and reported lower adverse effects, LCP-Tac became the tacrolimus preparation of choice at our transplant center for conversion in the setting of the Tac-IR national shortage.