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Papers of the Week

2020 May 22

Clin Trials

Adjudication of cardiovascular events in patients with chronic obstructive pulmonary disease: SUMMIT trial.


Wise RA, Anderson JA, Amarenco P, Cowans NJ, Crim C, Denvir MA, Gomez CR, Jones M P, Morris A, Niewoehner D, Yates JC
Clin Trials. 2020 May 22:1740774520920897.
PMID: 32441114.


Adjudicated cause-specific mortality has been used in major trials of chronic obstructive pulmonary disease. However, there is less experience with adjudicated major adverse cardiovascular events as a key efficacy outcome in chronic obstructive pulmonary disease trials. The Study to Understand Mortality and Morbidity in chronic obstructive pulmonary disease trial required a Clinical Endpoint Committee to adjudicate the outcomes of modified major adverse cardiovascular events and cause-specific mortality.