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Papers of the Week

Papers: 16 May 2020 - 22 May 2020

Pharmacology/Drug Development

2020 May 21

Oral Dis

The role of peripheral opioid receptors in orofacial pain.


Liu Q, Fan W, He H, Huang F
Oral Dis. 2020 May 21.
PMID: 32437594.


Opioid receptors are widely distributed in the central and peripheral nervous systems and non-neuronal tissues. Numerous researchers have noted the pivotal role of peripheral opioid receptors (PORs) in analgesia. Accumulating evidence has shown the existence of PORs in the trigeminal nerve system, indicating that PORs may be involved in the modulation of orofacial pain. In this review, we summarise the recent evidence for the role of PORs in orofacial pain and discuss the possible cellular mechanisms.