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Papers of the Week

Papers: 16 May 2020 - 22 May 2020

Human Studies, Pharmacology/Drug Development

2020 May 19

Clin J Pain

No Evidence of Altered Reactivity to Experimentally-induced Pain Among Regular Cannabis Users.



Recent years have seen an increase in the adoption of cannabinoid medicines, which have demonstrated effectiveness for the treatment of chronic pain. However, the extent to which frequent cannabis use (CU) influences sensitivity to acute pain has not been systematically examined. Such a determination is clinically relevant in light of hypersensitivity to pain associated with prolonged use of other analgesics such as opioids, and reports of increased pain sensitivity to experimentally induced pain during acute cannabis intoxication. This study will explore differences on measures of pain intensity and tolerance. We hypothesize that individuals who report frequent CU will demonstrate greater experimental pain sensitivity.