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Papers of the Week

2020 May

Open Forum Infect Dis



Early Amplified Respiratory Bioactive Lipid Response Is Associated With Worse Outcomes in Pediatric Influenza-Related Respiratory Failure.


Anania VG, Randolph AG, Yang X, Nguyen A, Newhams MM, Mathews RW, Rosenberger CM, McBride JM
Open Forum Infect Dis. 2020 May; 7(5):ofaa122.
PMID: 32420403.


Biomarkers are needed for early identification of patients at risk of severe complications from influenza infection, including prolonged respiratory failure and death. Eicosanoids are bioactive lipid mediators with pro- and anti-inflammatory properties produced in response to infection. This study assessed the relationships between the host bioactive lipid response, influenza viral load, and clinical outcomes.