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Papers of the Week

2020 May 13

Neurogastroenterol Motil

Localisation analysis of nerves in the mouse pancreas reveals the sites of highest nerve density and nociceptive innervation.


Saricaoglu Ö C, Teller S, Wang X, Wang S, Stupakov P, Heinrich T, Istvanffy R, Friess H, Ceyhan GO, Demir I E
Neurogastroenterol Motil. 2020 May 13:e13880.
PMID: 32406093.


Neuropathy and neuro-inflammation drive the severe pain and disease progression in human chronic pancreatitis and pancreatic cancer. Mice, especially genetically induced-mouse models, have been increasingly utilized in mechanistic research on pancreatic neuropathy, but the normal "peripheral neurobiology" of the mouse pancreas has not yet been critically compared to human pancreas.