I am a
Home I AM A Search Login

Papers of the Week

2020 Apr 29

Mult Scler Relat Disord


Cryptococcal meningitis in a patient with multiple sclerosis on dimethyl fumarate treatment: A case report.


Workel HH, Wolfhagen MJHM, Bouwhuis JW, Kloosterziel ME
Mult Scler Relat Disord. 2020 Apr 29; 42:102137.
PMID: 32408151.


We present a case of meningitis caused by Cryptococcus neoformans var. grubii in a 46-year old non-HIV-infected patient with multiple sclerosis, treated with dimethyl fumarate monotherapy. We identified no other risk factors for developing cryptococcal meningitis. The patient presented with a slowly progressive headache during preceding weeks and acute onset of confusion, nausea and vomiting. Clinical examination revealed intermittent disorientation without focal neurological symptoms. A lumbar puncture showed an opening pressure of > 50cmHO. Diagnosis of cryptococcal meningitis was made after culture of Cryptococcus neoformans var. grubii of cerebrospinal fluid.