I am a
Home I AM A Search Login

Papers of the Week

Papers: 9 May 2020 - 15 May 2020

Animal Studies

2020 May 14


A novel immunocompetent model of metastatic prostate cancer-induced bone pain.


Liu Z, Murphy SF, Huang J, Zhao L, Hall CC, Schaeffer AJ, Schaeffer EM, Thumbikat P
Prostate. 2020 May 14.
PMID: 32407603.


Over 70% to 85% of men with advanced prostate cancer (PCa) develop bone metastases characterized by severe bone pain and increased likelihood of bone fracture. These clinical features result in decreased quality of life and act as a predictor of higher mortality. Mechanistically, the skeletal pathologies such as osteolytic lesions and abnormal osteoblastic activity drive these symptoms. The role of immune cells in bone cancer pain remains understudied, here we sought to recapitulate this symptomology in a murine model.