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Papers of the Week

Papers: 9 May 2020 - 15 May 2020

Animal Studies

2020 May 08

Cell Mol Gastroenterol Hepatol

Inhibition of Microglial Activation in the Amygdala Reverses Stress-induced Abdominal Pain in the Male Rat.


Yuan T, Manohar K, Latorre R, Orock A, Meerveld B G-V
Cell Mol Gastroenterol Hepatol. 2020 May 08.
PMID: 32408032.


Psychological stress is a trigger for the development of irritable bowel syndrome (IBS) and associated symptoms including abdominal pain. Although IBS patients exhibit increased activation in the limbic brain, including the amygdala, the underlying molecular and cellular mechanisms regulating visceral nociception in the central nervous system (CNS) are incompletely understood. In a rodent model of chronic stress, we explored the role of microglia in the central nucleus of amygdala (CeA) in controlling visceral sensitivity. Microglia are activated by environmental challenges such as stress, and are able to modify neuronal activity via synaptic remodeling and inflammatory cytokine release. Inflammatory gene expression and microglial activity are negatively regulated by nuclear glucocorticoid receptors (GR), which are suppressed by the stress-activated pain mediator P38 MAPK.