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Papers of the Week

Papers: 9 May 2020 - 15 May 2020

Animal Studies, Pharmacology/Drug Development

2020 May 09

Psychopharmacology (Berl)

HDAC6-selective inhibitors decrease nerve-injury and inflammation-associated mechanical hypersensitivity in mice.


Sakloth F, Manouras L, Avrampou K, Mitsi V, Serafini RA, Pryce KD, Cogliani V, Berton O, Jarpe M, Zachariou V
Psychopharmacology (Berl). 2020 May 09.
PMID: 32388618.


HDAC6 is a class IIB histone deacetylase expressed at many levels of the nociceptive pathway. This study tested the ability of novel and selective HDAC6 inhibitors to alleviate sensory hypersensitivity behaviors in mouse models of peripheral nerve injury and peripheral inflammation.