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Papers of the Week

2020 May 07

Int Urol Nephrol

Effect of mirtazapine on pruritus in patients on hemodialysis: a cross-over pilot study.


Gholyaf M, Sheikh V, Yasrebifar F, Mohammadi Y, Mirjalili M, Mehrpooya M
Int Urol Nephrol. 2020 May 07.
PMID: 32383050.


Uremic pruritus (UP) is a highly prevalent and disturbing problem in patients with advanced chronic kidney disease (CKD); however, treatment of UP is largely unsatisfactory. The present study was designed to investigate the effectiveness of mirtazapine, an atypical antidepressant agent with potent antagonistic activity against serotonin (5HT2, 5HT3) and histamine (H1) receptors, in the treatment of pruritus in hemodialysis (HD) patients.