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Papers of the Week

Home / Publications / Pain Research Forum / Papers of the Week / Effect of mirtazapine on pruritus in patients on hemodialysis: a cross-over pilot study.

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2020 May 07


Int Urol Nephrol


http://www.ncbi.nlm.nih.gov/pubmed/32383050?dopt=Abstract

Effect of mirtazapine on pruritus in patients on hemodialysis: a cross-over pilot study.

Authors

Effect of mirtazapine on pruritus in patients on hemodialysis: a cross-over pilot study.
Gholyaf M, Sheikh V, Yasrebifar F, Mohammadi Y, Mirjalili M, Mehrpooya M
Int Urol Nephrol. 2020 May 07.
PMID: 32383050.

Abstract

Uremic pruritus (UP) is a highly prevalent and disturbing problem in patients with advanced chronic kidney disease (CKD); however, treatment of UP is largely unsatisfactory. The present study was designed to investigate the effectiveness of mirtazapine, an atypical antidepressant agent with potent antagonistic activity against serotonin (5HT2, 5HT3) and histamine (H1) receptors, in the treatment of pruritus in hemodialysis (HD) patients.
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