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Papers of the Week

2020 May 04

Virus Res



Nwafor Ifeanyi E, Emeka O O, Ojide Chiedozie K, Odeh Elizabeth C, Abu Augustine M, Chika-Igwenyi Nneka M, Nwidi Demian U, Unigwe Uche S, Ajayi Nnenna A, Eke Matthew AS, Mary O, Azuka A, Venatius O, Rosemary D, Igboke Nancy C, Josephine O, Ogbonnaya O
Virus Res. 2020 May 04:198000.
PMID: 32380207.


Lassa fever (LF) is a viral hemorrhagic illness endemic in West Africa. Annually, about 300,000 – 500,000 people are being infected, with about 5,000 deaths. Symptoms of LF include high grade fever, headache, malaise, abdominal pain, vomiting, diarrhea, or sore throat. Terminal features may include bleeding from all orifices (mouth, nose, ear, anus and vagina), facial and neck oedema or pleural effusion. People of all ages, gender, and occupations were included in this study. A total of 440 patients' samples and Bio data were used for this study. The samples were analyzed for Lassa fever virus RNA using Real Time Reverse Transcriptase Polymerase Chain Reaction. The data obtained were analyzed using SPSS 20.0 and version 7 of Epi-Info statistical software. Analysis of these samples showed LASV prevalence of 25.7 %. Chi-square analysis (p 0.05) showed that LASV infection does not depend on age, gender, or occupation. Our research re-emphasized the fact that LASV is a serious cause of fatality in humans. Our data showed that among 327 negative patients, 19 died. On the contrary, 113 LASV confirmed positive cases had 42 deaths. This result is highly significant. More so, Lassa fever disease outcome was compared across gender. There was no significant difference between the two genders. Death or recovery from LF infection does not depend on sex. However, recovery from LF significantly depend on age of the patient. Fatal outcome is significantly higher among adults/elderly. We aim to raise awareness to the recurrence of LASV in Ebonyi State and urgent need for other medical interventions, including other therapeutic measures, and possible vaccine production, considering the impact of this virus.