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Papers of the Week

2020 Apr 29

Support Care Cancer

Lipid microsphere bound oxycodone for pain management in patients receiving radiotherapy for head and neck cancer.


McDonald AM, Spencer SA, Willey CD, Bonner JA, Dobelbower MC, Swain TA, Nabell L, McCammon S, Carroll WR, McGwin G, Bhatia S, Yang ES
Support Care Cancer. 2020 Apr 29.
PMID: 32350670.


Wax microsphere bound oxycodone was developed as an abuse-deterrent opioid and maintains a similar pharmacokinetic profile whether administered with or without an intact capsule. We hypothesized that microsphere oxycodone could be utilized for extended release analgesia in patients undergoing radiation (RT) for head-and-neck cancer (HNC) and would not need to be discontinued due to dysphagia or gastrostomy tube dependence.