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Papers of the Week

2020 Jan-Apr

Case Rep Oncol



Short-Term Outcome and MRI Changes in Three Adult Patients with Sickle Cell Disease and Aseptic Osteonecrosis after Treatment with Hyperbaric Oxygen Therapy: A Preliminary Report.


Shier A, Abdelrazek M, Soliman A, De Sanctis V, Elsayed A, Abdulla M, Mohamed S, Yassin K, Bilal I, Yassin M
Case Rep Oncol. 2020 Jan-Apr; 13(1):365-372.
PMID: 32355491.


Musculoskeletal manifestations are common in sickle cell disease (SCD). Vaso-occlusive crisis can manifest acutely as joint and bone pain, osteomyelitis and/or arthritis. It can also lead to chronic bone aches, bone deformities, degenerative arthritis, pathological fractures, and osteoporosis. Hyperbaric oxygen (HBO) therapy is a mode of treatment in which the patient is exposed to very high arterial and tissue oxygen pressure, during multiple sessions. It has been used as primary or adjunctive therapy for a variety of medical disorders, including necrotizing infection and sickle cell crisis.