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Papers of the Week

Papers: 2 May 2020 - 8 May 2020

Human Studies


2020 Apr 30

Eur J Neurol

Cold extremities in migraine: a marker for vascular dysfunction in women.


Linstra KM, Perenboom MJL, van Zwet EW, van Welie FC, Fronczek R, Tannemaat MR, Wermer MJH, Maassen Van Den Brink A, Terwindt GM
Eur J Neurol. 2020 Apr 30.
PMID: 32356361.


Migraine is recognized as a vascular risk factor, especially in women. Presumably, migraine, stroke and cardiovascular events share pathophysiological mechanisms. We investigated self-reported cold extremities as a marker for vascular dysfunction in migraine. Secondly, we hypothesized that suffering from cold extremities affects sleep quality, possibly exacerbating migraine attack frequency.