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Papers of the Week

Papers: 25 Apr 2020 - 1 May 2020

Animal Studies

2020 Jan-Dec

Mol Pain


Chemokine receptor CXCR4 activates the RhoA/ROCK2 pathway in spinal neurons that induces bone cancer pain.


Xu H, Peng C, Chen X-T, Yao Y-Y, Chen L-P, Yin Q, Shen W
Mol Pain. 2020 Jan-Dec; 16:1744806920919568.
PMID: 32349612.


Chemokine receptor CXCR4 has been found to be associated with spinal neuron and glial cell activation during bone cancer pain. However, the underlying mechanism remains unknown. Furthermore, the RhoA/ROCK2 pathway serves as a downstream pathway activated by CXCR4 during bone cancer pain. We first validated the increase in the expressions of CXCR4, p-RhoA, and p-ROCK2 in the spinal dorsal horn of a well-characterized tumor cell implantation-induced cancer pain rat model and how these expressions contributed to the pain behavior in tumor cell implantation rats. We hypothesized that spinal blockade of the CXCR4-RhoA/ROCK2 pathway is a potential analgesic therapy for cancer pain management.