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Papers of the Week

Papers: 25 Apr 2020 - 1 May 2020

Human Studies


2020 Apr 29


Identification of candidate proteomic markers in the serum of medication overuse headache patients: An exploratory study.


Pellesi L, Guerzoni S, Baraldi C, Cainazzo M M, Pini L A, Bellei E
Cephalalgia. 2020 Apr 29:333102420921847.
PMID: 32347744.


The pathophysiological mechanism of medication overuse headache is uncertain; no distinctive markers have been described right now. The aim of this study was to conduct proteomic analyses on serum samples from patients with medication overuse headache and healthy individuals. Specifically, mono- (SDS-PAGE) and two-dimensional gel electrophoresis (2-DE) followed by liquid chromatography tandem mass spectrometry (LC-MS/MS) were used to evaluate changes in serum proteins.