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Papers of the Week

2020 Mar

ACG Case Rep J



Hepatitis E Infection With Acute Liver Failure.


Phan T, Desmond C
ACG Case Rep J. 2020 Mar; 7(3):e00361.
PMID: 32337319.


A 21-year-old man from India presented with acute hepatitis associated with a 1-week history of abdominal pain, pruritus, and dark urine. Over a 7-day admission, the patient's acute hepatitis evolved into acute liver failure with low-grade encephalopathy, markedly elevated transaminases, bilirubin, and impaired hepatic synthetic function. He was eventually diagnosed with acute hepatitis E virus (HEV) and was transitioned to supportive management. Acute HEV is a rare cause of acute liver failure. Hence, this case highlights the importance of early consideration of HEV in all patients with acute hepatitis who have originated from endemic regions.