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Papers of the Week

2020 Apr 25

Br J Pharmacol

Cloning and characterization of the rat Slo3 channel: from biophysics to pharmacology.


Wang G-M, Zhong Z-G, Du X-R, Zhang F-F, Guo Q, Liu Y, Tang Q-Y, Zhang Z
Br J Pharmacol. 2020 Apr 25.
PMID: 32335912.


The Slo3 potassium channel, which is specifically expressed in the testis and sperm, is essential for mammalian male fertilization. The sequence divergence of the bovine, mouse, and human Slo3 α-subunit revealed a rapid evolution rate across different species. The rat Slo3 (rSlo3) channel has not been cloned and characterized previously.