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Papers of the Week
Cloning and characterization of the rat Slo3 channel: from biophysics to pharmacology.
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Abstract
The Slo3 potassium channel, which is specifically expressed in the testis and sperm, is essential for mammalian male fertilization. The sequence divergence of the bovine, mouse, and human Slo3 α-subunit revealed a rapid evolution rate across different species. The rat Slo3 (rSlo3) channel has not been cloned and characterized previously.