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Papers of the Week

Papers: 25 Apr 2020 - 1 May 2020

Human Studies

2020 Apr 26

Eur J Pain

Peripheral input and phantom limb pain: a somatosensory event-related potential study.


Liu H, Andoh J, Lyu Y, Milde C, Desch S, Zidda F, Schmelz M, Curio G, Flor H
Eur J Pain. 2020 Apr 26.
PMID: 32335979.


Following amputation, nearly all amputees report non-painful phantom phenomena and many of them suffer from chronic phantom limb pain (PLP) and residual limb pain (RLP). The etiology of PLP remains elusive and there is an ongoing debate on the role of peripheral and central mechanisms. Few studies have examined the entire somatosensory pathway from the truncated nerves to the cortex in amputees with PLP compared to those without PLP. The relationship between afferent input, somatosensory responses and the change in PLP remains unclear.