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Papers of the Week

2020 Apr

CNS Spectr



103 Atypical Progressive Bulbar Palsy presenting with Dropped Head.


Carvajal-González A, Iglesias AH
CNS Spectr. 2020 Apr; 25(2):267.
PMID: 32331014.


Typical amyotrophic lateral sclerosis (ALS) presents on neurological examination with specific signs of upper and lower motor neuron degeneration (Brooks et al, 1995), which can account for 85% of patients with ALS (Turner and Talbot, 2013). There are different types of clinical presentations, including progressive bulbar palsy (PBP), Limb-onset ALS, progressive muscular atrophy (PMA) and upper motor neuron (UMN) predominant ALS. PBP has mainly brainstem signs. There are a few case reports of dropped head syndrome in ALS, mainly in patients with the limb involvement variant.