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Papers of the Week

2020 Apr 24

Neurourol Urodyn

Medications used to treat bladder disorders may alter effects of neuromodulation.


Ness TJ, McNaught J, Clodfelder-Miller B, Su X
Neurourol Urodyn. 2020 Apr 24.
PMID: 32330365.


Neuromodulation (nerve stimulation) can produce analgesia. One form, bilateral pudendal nerve stimulation (bPNS), suppresses responses to urinary bladder distension (UBD) in hypersensitive rats. Drugs can modify this effect (eg, benzodiazepines, but not opioids, suppress bPNS effects). Prior to a clinical trial of bPNS effects on bladder pain, we felt it was prudent to survey the effects of medications commonly used in patients with bladder disorders.