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Papers of the Week

2020 Apr 23

Intern Med

A Case of Neuromyelitis Optica Spectrum Disorder Complicated by Posterior Reversible Encephalopathy Syndrome as an Initial Manifestation.


Shima T, Tsujino S, Yamashita K, Hirayama T, Fukushima K, Kanamoto T, Ohta R, Nagaoka A, Yoshimura S, Miyazaki T, Tateishi Y, Shiraishi H, Tsujino A
Intern Med. 2020 Apr 23.
PMID: 32321890.


A 25-year-old woman was admitted to our hospital due to tonic convulsion with severe headache after having experienced symptoms of nausea and vomiting for a month. Brain MRI showed extensive symmetrical lesions in the cortical and subcortical areas of parieto-occipital lobes and basal ganglia, consistent with typical characteristics of posterior reversible encephalopathy syndrome (PRES). Furthermore, some residual lesions in the left side of dorsal medulla oblongata and central area of the cervical spinal cord along with the presence of serum anti-aquaporin-4 antibody yielded the diagnosis of neuromyelitis optica spectrum disorder (NMOSD). We herein discuss the mechanism by which PRES may occur together with NMOSD.