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2020 Mar 20

Zhonghua Gan Zang Bing Za Zhi



[Clinical features and outcome of treatment for novel coronavirus pneumonia: a meta-analysis].


Wu YY, Li HY, Xu XB, Zheng KX, Qi XS, Guo XZ
Zhonghua Gan Zang Bing Za Zhi. 2020 Mar 20; 28(3):240-246.
PMID: 32306657.


To investigate the clinical features and outcome of treatment for novel coronavirus pneumonia. Literature on novel coronavirus pneumonia was retrieved from PubMed and EMBASE databases. The relevant data was extracted and a meta-analysis was performed using StatsDirect statistical software V.2.8.0 to calculate the combined odds ratio. Seven studies were included, consisting of 1594 cases. The meta-analysis result showed that the most common clinical symptoms of the novel coronavirus pneumonia were fever (91.6%) and cough (64.5%), followed by dyspnea (32.8%) and sputum (28.1%). Headache (10.5%), sore throat (11.2%), hemoptysis (3.2%), diarrhea (6.6%) and the other symptoms were relatively rare. Aspartate aminotransferase (29%), alanine transaminase (22.7%), and total bilirubin (11.7%) levels were elevated, except for serum albumin levels (80.4%). The common therapeutic agents used were antibiotics (87.7%), antiviral drugs (75.5%), and glucocorticoids (26.6%), while antifungal agents (7.7%) were used in few. Mechanical ventilation (13.4%), extracorporeal membrane oxygenation (1.9%), and continuous renal replacement therapy (3.8%) were used in severe cases. The rate of mortality in hospital was 7.7%, respectively. Heterogeneity between studies was significant; however, subgroup and sensitivity analysis had failed to identify clear sources of heterogeneity. Fever, cough and liver dysfunction are the main clinical manifestations of this disease and the mortality rate is low.