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Papers of the Week


Int J Nanomedicine


p66shc siRNA Nanoparticles Ameliorate Chondrocytic Mitochondrial Dysfunction in Osteoarthritis.


Shin H J, Park H W, Shin N, Shin J, Gwon D H, Kwon H H, Yin Y, Hwang J-A, Hong J, Heo J Y, Kim C-S, Joo Y, Kim Y, Kim J H, Beom J, Kim D W
Int J Nanomedicine. 2020; 15:2379-2390.
PMID: 32308389.


Osteoarthritis (OA) is the most common type of joint disease associated with cartilage breakdown. However, the role played by mitochondrial dysfunction in OA remains inadequately understood. Therefore, we investigated the role played by p66shc during oxidative damage and mitochondrial dysfunction in OA and the effects of p66shc downregulation on OA progression.