I am a
Home I AM A Search Login

Papers of the Week

2020 Apr 17

Mol Metab

Hypothalamic Pomc expression restricted to GABAergic neurons suppresses Npy overexpression and restores food intake in obese mice.


Trotta M, Bello E P, Alsina R, Tavella M B, Ferrán J L, Rubinstein M, Bumaschny V F
Mol Metab. 2020 Apr 17:100985.
PMID: 32311511.


Hypothalamic arcuate proopiomelanocortin (Arc-POMC) neurons are involved in different physiological processes such as the regulation of energy balance, glucose homeostasis and stress induced analgesia. Since these neurons heterogeneously express different biological markers and project to many hypothalamic and extrahypothalamic areas, it is proposed that Arc-POMC neurons could be classified into different subpopulations having diverse physiological roles. The aim of the present study was to characterize the contribution of the subpopulation of Arc-POMC neurons co-secreting gamma-aminobutyric acid (GABA) neurotransmitter in the control of energy balance.