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Papers of the Week

2020 Apr 16

Curr Opin Support Palliat Care

Current Opinion in Supportive and Palliative Care 2020 section: Opioid analgesia: recent developments.


Opioids are potent drugs for the treatment of severe pain, but they are burdened by detrimental side-effects, such as respiratory depression, addiction, sedation and constipation. Their clinical application is undisputed in acute (e.g. perioperative) and cancer pain, but their use in chronic nonmalignant pain has met increasing scrutiny and has contributed to the opioid crisis. Thus, novel analgesics with reduced side-effects are badly needed.